Great Lakes
The northern Midwest can be traversed by boat throughout the Great Lakes. Many boaters utilize the Great Lakes, St. Lawrence Seaway and their connection points as a travel route. The Lakes Cruising Company (http://greatlakescruising...) and the American Canadian Caribbean Line (http://accl-smallships.com/) provide cruises with several Midwest cities including Chicago, Cleveland, Detroit, Milwaukee in their itineria.
By bus
Greyhound offers passenger bus service from many U.S. cities.
Megabus is a low-cost bus company primarily offering service in the Midwest connecting its hub in Chicago to Ann Arbor, Cincinnati, Cleveland, Columbus, Des Moines, Detroit, Indianapolis, Kansas City, Memphis, Milwaukee, Minneapolis, St. Louis and Toledo.
By plane
The Midwest is served by several international airports, including many of the major US airlines' national hubs. Chicago-O'Hare United and American, Cleveland Continental, Cincinnati-Northern Kentucky Delta, Detroit Delta, Minneapolis-Saint Paul Delta, Milwaukee Midwest and Saint Louis-Lambert American. Many major metropolitan areas also have secondary international and regional airports, supporting discount airlines.
By train
Amtrak also operates several routes through the Midwest, including several that primarily connect Chicago directly to other major Midwest cities. The major routes running through several Midwest states and major cities include:
Capitol Limited Chicago, Cleveland and onto Washington, D.C.
Cardinal/Hoosier State Chicago, Indianapolis, Cincinnati and onto Washington, D.C. and New York City
Empire Builder Chicago, Milwaukee, Minneapolis-Saint Paul and onto Seattle or Portland
Lake Shore Limited Chicago, Cleveland and onto New York City or Boston
Texas Eagle Chicago, St. Louis and onto Texas
California Zephyr Chicago onto Denver and the San Francisco Bay Area